Using lasers to improve gene delivery to the cornea
Amplified femtosecond laser permeabilization and poration for nonviral corneal gene delivery
This study is exploring a gentle new way to deliver gene therapy to the eye using a special laser that creates tiny channels in the cornea, making it easier for helpful DNA to get in without causing any harm, which could lead to better treatment options for people with corneal diseases or injuries.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11057876 on NIH RePORTER |
What this research studies
This research investigates a new method for delivering gene therapy to the cornea using femtosecond laser technology. The approach aims to create microchannels in the corneal epithelium, allowing therapeutic DNA to penetrate more effectively without damaging the tissue. By avoiding the need for invasive procedures that can cause discomfort and complications, this method seeks to enhance the safety and efficacy of gene therapy for eye conditions. Patients may benefit from improved treatment options for corneal diseases and injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with corneal diseases or injuries that may benefit from gene therapy.
Not a fit: Patients with conditions unrelated to the cornea or those who do not require gene therapy may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective way to deliver gene therapy for various corneal conditions.
How similar studies have performed: Previous research has shown promise in using laser technology for enhancing drug delivery, indicating potential success for this novel approach.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Bradford, Samantha — University of California-Irvine
- Study coordinator: Bradford, Samantha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.