Using Jagged1 to regenerate craniofacial bone in children
Jagged1-based craniofacial bone regeneration
This study is exploring a new way to help kids grow back craniofacial bone that they may have lost due to injury or birth conditions, using a special protein called Jagged1 that could be safer than current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11080375 on NIH RePORTER |
What this research studies
This research focuses on developing a new method to regenerate craniofacial bone in children who have experienced bone loss due to trauma or congenital conditions. The approach involves using a protein called Jagged1, which has shown promise in laboratory studies for promoting bone growth without the risks associated with current methods like autologous bone grafts. By engineering and testing this therapy, the research aims to provide a safer and more effective solution for pediatric patients needing craniofacial reconstruction. The study will involve both laboratory experiments and potential clinical applications to assess the effectiveness of Jagged1 in stimulating bone regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with craniofacial bone loss due to traumatic injuries or congenital conditions like Alagille syndrome.
Not a fit: Patients who do not have craniofacial bone loss or those who are adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a groundbreaking treatment option for children suffering from craniofacial bone loss, reducing the need for invasive surgeries.
How similar studies have performed: While there have been successful regenerative strategies for adults, this approach using Jagged1 in children is novel and has not been extensively tested before.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Goudy, Steven L — Emory University
- Study coordinator: Goudy, Steven L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.