Using histones to enhance the killing of harmful bacteria
Synergistic killing of bacterial pathogens by histones
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10884219
This study is looking at how certain proteins can work with natural antibiotics to help fight tough bacterial infections in people with diabetes, aiming to find new ways to treat infections that don't respond to regular antibiotics.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10884219 on ClinicalTrials.gov |
What this research studies
This research investigates how histones, proteins involved in DNA packaging, can be used in combination with antimicrobial peptides to effectively kill bacteria that cause chronic infections, particularly in patients with diabetes. The approach focuses on understanding the mechanisms by which these proteins and peptides work together to disrupt bacterial function and promote bacterial death. By studying the interactions between histones and antimicrobial peptides, the research aims to develop new treatments for antibiotic-resistant bacterial infections that are difficult to manage.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from chronic bacterial infections, particularly those with diabetes who are at risk for non-healing wounds.
Not a fit: Patients with infections caused by bacteria that are not targeted by this research or those who do not have chronic infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antimicrobial therapies that effectively treat chronic bacterial infections, especially in patients with antibiotic-resistant strains.
How similar studies have performed: Other research has shown promising results in using similar approaches to enhance antimicrobial efficacy, indicating potential for success in this area.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIRYAPORN, ALBERT — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SIRYAPORN, ALBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections