Using genome editing to improve diagnosis and treatment of heart diseases
Diagnosis, Prevention, And Treatment Of Cardiovascular Diseases With Genome Editing
This study is exploring new ways to use gene editing to better understand and treat heart disease, aiming to find out how certain genes affect cholesterol and heart health, which could lead to more personalized and effective treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11042782 on NIH RePORTER |
What this research studies
This research focuses on understanding and addressing cardiovascular diseases through innovative genome editing techniques. By studying specific genes related to lipid metabolism and coronary heart disease, the research aims to uncover new mechanisms that contribute to these conditions. Patients may benefit from advancements in disease modeling and therapeutic genome editing, which could lead to improved prevention and treatment strategies for heart disease. The research also seeks to clarify the significance of genetic variants found in patients, enhancing personalized medicine approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for coronary heart disease, those with genetic predispositions to cardiovascular conditions, and patients with uncertain genetic variants related to heart health.
Not a fit: Patients with established cardiovascular diseases who are not genetically predisposed or those without relevant genetic variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking methods for preventing and treating cardiovascular diseases, potentially saving lives.
How similar studies have performed: Previous research has shown promise in using genome editing for various genetic conditions, suggesting potential success in this novel approach for cardiovascular diseases.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Musunuru, Kiran — University of Pennsylvania
- Study coordinator: Musunuru, Kiran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.