Using genetic risk scores to improve disease prediction and patient care
Rational Integration of Polygenic Risk Scores (RIPS)
This study is looking at how using genetic risk scores can help doctors better predict and manage complex diseases like breast cancer and heart disease, making sure that everyone can benefit from this approach.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11045024 on NIH RePORTER |
What this research studies
This research investigates how polygenic risk scores (PRS) can be effectively integrated into clinical practice to predict complex diseases like breast cancer and cardiovascular diseases. By analyzing long-term patient outcomes and identifying optimal risk thresholds, the study aims to enhance the cost-effectiveness of patient care. The researchers will use decision analytic modeling to evaluate the clinical and economic impacts of population screening based on these genetic scores, ensuring that the benefits are accessible across diverse populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for common complex diseases such as breast cancer and atherosclerotic cardiovascular disease.
Not a fit: Patients with rare genetic disorders or those not at risk for the targeted conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate disease predictions and tailored prevention strategies for patients based on their genetic profiles.
How similar studies have performed: Previous research has shown promising results in using genetic risk scores for disease prediction, indicating that this approach has potential for significant advancements in patient care.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Peterson, Joseph F. — Vanderbilt University Medical Center
- Study coordinator: Peterson, Joseph F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.