Using gene-edited stem cells to enhance heart transplant outcomes
Cardiac Regenerative Therapy Using Gene-Edited Stem Cells to Improve Transplantation Outcomes
This study is exploring a new way to help people with severe heart failure by using special stem cells that have been modified to better survive and heal the heart, especially for those who haven't had success with regular treatments after a heart attack.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10905166 on NIH RePORTER |
What this research studies
This research focuses on improving heart function in patients with end-stage heart failure by using gene-edited stem cells. The approach involves targeting inflammatory pathways that contribute to the loss of transplanted cells, which is a major barrier to successful treatment. By enhancing the survival and retention of these stem cells, the research aims to regenerate heart tissue and improve overall cardiac function. Patients who have suffered from heart attacks and have not responded well to traditional therapies may benefit from this innovative treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing end-stage heart failure due to myocardial infarction.
Not a fit: Patients with heart failure not related to myocardial infarction or those who are not candidates for stem cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart function and survival rates for patients with severe heart failure.
How similar studies have performed: Previous research has shown promise in using stem cell therapy for heart regeneration, but this specific approach targeting inflammation is novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Sirish, Padmini — University of California at Davis
- Study coordinator: Sirish, Padmini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.