Using extracellular vesicles to predict how children will respond to antidepressants for anxiety
Estracellular Vesicles as Non-Invasive Predictors of Antidepressant Outcomes in Pediatric Anxiety
This study is looking at tiny particles in the blood that might help us understand how well kids and teens with anxiety will respond to antidepressant medications, so we can create more personalized treatment plans just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10649525 on NIH RePORTER |
What this research studies
This research investigates how extracellular vesicles, which are tiny particles released by cells, can serve as non-invasive indicators of how well children and adolescents will respond to antidepressant medications for anxiety disorders. By analyzing these vesicles, the study aims to identify biological markers that can predict treatment outcomes and potential side effects associated with selective-serotonin reuptake inhibitors (SSRIs). This approach seeks to improve the management of anxiety disorders in young patients by providing insights that could lead to more personalized treatment plans. The research involves collecting blood samples from participants to analyze the vesicles and their contents.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with anxiety disorders who are being considered for treatment with SSRIs.
Not a fit: Patients who do not have anxiety disorders or who are not candidates for SSRI treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictions of treatment responses, allowing for more effective and tailored antidepressant therapies for children and adolescents with anxiety disorders.
How similar studies have performed: While the use of biological markers in predicting treatment outcomes is an emerging field, this specific approach using extracellular vesicles is relatively novel and has not been extensively tested in pediatric populations.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Strawn, Jeffrey Robert — University of Cincinnati
- Study coordinator: Strawn, Jeffrey Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.