Using D-serine to improve auditory learning in people with schizophrenia
D-serine augmentation of neuroplasticity-based auditory learning in schizophrenia
This study is looking at whether D-serine can help improve how people with schizophrenia process sounds and boost their memory and thinking skills through special training exercises.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10489322 on NIH RePORTER |
What this research studies
This research investigates how D-serine, a compound that enhances neuroplasticity, can improve auditory processing in individuals with schizophrenia. The study focuses on training exercises that challenge early auditory information processing, aiming to boost cognitive functions like verbal memory and executive functioning. Participants will receive D-serine in varying doses alongside a neuroplasticity-based auditory remediation program to assess its effectiveness in enhancing learning and cognitive performance. The approach is designed to address a critical need for better treatment options in schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia who experience difficulties with auditory processing and cognitive functions.
Not a fit: Patients who do not have schizophrenia or those with other unrelated mental health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive functioning and daily living skills for individuals with schizophrenia.
How similar studies have performed: Previous research has shown that NMDAR glycine site agonists like D-serine can enhance neuroplasticity, indicating potential for success in this novel approach.
Where this research is happening
New York, United States
- New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC — New York, United States (Active)
Researchers
- Principal investigator: Kantrowitz, Joshua Tolkien — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Kantrowitz, Joshua Tolkien
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.