Using CRISPR technology to identify genes affecting heart development in zebrafish
Official title: Developing a CRISPR-based forward-genetic screening method in embryonic zebrafish
Funded at Brigham Young University · NIH-10974321 · Data updated 2026-11-12
This study is exploring a new way to find out which genes affect heart development in zebrafish, using a special tool called CRISPR, to help us better understand how hearts grow and could eventually help in other animals too.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham Young University NIH-funded |
| Lab location | 1 site (Provo, United States) |
| Project start | August 1, 2019 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $449,350 |
| NIH project number | 2R15HD098969-02A1 |
| Project ID | NIH-10974321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of congenital heart defects or those interested in genetic factors affecting heart development.
✕Less likely to help
Patients with conditions unrelated to genetic mutations affecting heart development may not benefit from this research.
What this research studies
This research focuses on developing a new method to identify genes and mutations that influence embryonic development, particularly in the heart of zebrafish. By utilizing CRISPR technology, the researchers aim to create a library of genetic tools that can efficiently target specific genes. The approach involves injecting CRISPR components into zebrafish embryos to observe the effects on heart morphology, which helps in understanding the genetic basis of heart development. This method not only aims to improve the efficiency of genetic screening but also has the potential to be adapted for use in various tissues and species.
Why it matters
Potential benefit: If successful, this research could lead to faster identification of genetic factors involved in heart development, potentially informing treatments for congenital heart defects.
How similar studies have gone: Other research using CRISPR technology for genetic screening has shown promising results, indicating that this approach could be effective.
Where this research is happening
-
Brigham Young University
Provo, United States Active
Researchers
- Principal investigator: Hill, Jonathon T — Brigham Young University
- Study coordinator: Hill, Jonathon T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.