Lipid isomer fingerprinting to better understand breast cancer biology
Official title: Simultaneous Separation, Identification, and Quantification of Lipid Isomers using Non-Covalent Chemistry-Based Enhancement of Tandem Ion Mobility-Mass Spectrometry
Funded at Brigham Young University · NIH-11430260 · Data updated 2026-11-12
A new method uses a special chemistry-enhanced analysis to separate and measure different lipid isomers in breast cancer samples.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham Young University NIH-funded |
| Lab location | 1 site (Provo, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $406,576 |
| NIH project number | 1R35GM166541-01 |
| Project ID | NIH-11430260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with breast cancer or related lipid biology conditions who may contribute tissue or blood samples for analytical analysis could benefit from advancements in biomarker discovery.
✕Less likely to help
Patients without breast cancer or relevant lipid biology samples may not directly benefit from this analytical platform.
What this research studies
This project aims to develop a unified analytical platform that uses non-covalent chemistry with cyclic ion mobility and mass spectrometry to distinguish lipid isomers more accurately. The approach will apply to various sample types and lipid classes, improving our ability to read lipid signals in breast cancer biology. By identifying which lipid isomers are linked to disease progression, patients may benefit from more precise biomarkers in the future.
Why it matters
Potential benefit: If successful, the method could enable better lipid-based biomarkers for breast cancer and related diseases, potentially guiding diagnosis or treatment in the future.
How similar studies have gone: Preliminary work has shown non-covalent modifications can separate isomers in small molecules; translation to lipids in complex biological samples is being explored.
Where this research is happening
-
Brigham Young University
Provo, United States Active
Researchers
- Principal investigator: Lee, Kenneth Wayne — Brigham Young University
- Study coordinator: Lee, Kenneth Wayne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.