Using creatine and resistance training to help maintain muscle and slow cancer progression in men with advanced prostate cancer
Official title: Creatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression: A double-blind randomized controlled trial
Funded at University of Utah · NIH-10913420 · Data updated 2026-11-12
This study is looking at whether taking creatine along with strength training can help men with advanced prostate cancer keep their muscle mass and improve their overall health, and by joining, you can help us learn how to better support cancer survivors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $651,255 |
| NIH project number | 5R01CA281759-02 |
| Project ID | NIH-10913420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with metastatic castration-sensitive prostate cancer who are undergoing androgen deprivation therapy.
✕Less likely to help
Patients with non-metastatic prostate cancer or those not receiving androgen deprivation therapy may not benefit from this research.
What this research studies
This research investigates the effects of creatine supplementation combined with resistance training on preserving muscle mass and improving health outcomes for men with metastatic castration-sensitive prostate cancer. Participants will engage in a 52-week program where they will receive either creatine or a placebo while undergoing resistance training. The study aims to determine if this combination can enhance muscle preservation and potentially influence cancer progression markers. By participating, patients may contribute to understanding how to better support cancer survivors' quality of life and physical function.
Why it matters
Potential benefit: If successful, this research could lead to improved muscle mass preservation and better overall health outcomes for men undergoing treatment for advanced prostate cancer.
How similar studies have gone: Previous research has shown that creatine supplementation can enhance muscle mass and physical function in various populations, suggesting potential success for this approach in cancer survivors.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Coletta, Adriana — University of Utah
- Study coordinator: Coletta, Adriana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.