Using corticosteroids to reduce inflammation in severe pancreatitis
Corticosteroids to Reduce Inflammation in Severe Pancreatitis (CRISP)
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11000279
This study is looking at whether giving a short course of corticosteroids early on can help people with severe acute pancreatitis feel better and avoid serious complications caused by inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11000279 on ClinicalTrials.gov |
What this research studies
This research investigates the use of corticosteroids, a common anti-inflammatory medication, to improve outcomes in patients suffering from severe acute pancreatitis. The study aims to administer a short course of physiologic-dose corticosteroids early in the treatment process, as inflammation is a major factor in the progression of this serious condition. By focusing on patients who are at risk of developing severe complications, the research seeks to determine if this approach can mitigate the systemic inflammatory response and improve overall patient health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with severe acute pancreatitis who are at risk of developing complications such as multi-organ failure.
Not a fit: Patients with mild pancreatitis or those with autoimmune pancreatitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option that significantly improves survival rates and recovery for patients with severe acute pancreatitis.
How similar studies have performed: While corticosteroids have shown promise in treating other inflammatory conditions, their application in pancreatitis is still under-researched, making this approach relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DONNINO, MICHAEL WILLIAM — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: DONNINO, MICHAEL WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome