Using cell factors to help heal the cornea
Phase I Study of Mesenchymal Stromal Cell Secretome for Promoting Corneal Regeneration
This study is looking at how special substances from bone marrow cells can help heal the eye's surface, and it's for people with corneal issues who want to improve their healing and vision safely.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11145412 on NIH RePORTER |
What this research studies
This research investigates the use of secreted factors from mesenchymal stromal cells derived from bone marrow to promote healing in the cornea. It aims to assess the safety of these factors on the ocular surface and observe their effects on epithelial healing, scarring, and visual acuity. The study will include a Phase 1 safety assessment and a Phase 2a controlled trial to gather preliminary evidence of effectiveness and identify which patients may benefit the most from this treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from significant non-healing corneal epithelial disease.
Not a fit: Patients with fully healed corneal epithelium or those with conditions unrelated to corneal healing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved healing and visual outcomes for patients with severe corneal epithelial diseases.
How similar studies have performed: Other research has shown promise in using cell-derived factors for tissue regeneration, suggesting potential success for this approach.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Djalilian, Ali R — University of Illinois at Chicago
- Study coordinator: Djalilian, Ali R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.