Using carbon monoxide to treat inflammation in the intestines
Examining Carbon Monoxide to Treat Inflammatory Conditions using Experimental Colitis Models
This study is looking at how carbon monoxide might help reduce inflammation and heal the intestines in people with colitis, using new ways to deliver it safely, which could lead to better treatment options for those with inflammatory bowel diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10654693 on NIH RePORTER |
What this research studies
This research investigates the therapeutic effects of carbon monoxide (CO) as an anti-inflammatory agent, particularly in treating conditions like colitis. The study aims to develop safe and effective delivery methods for CO, moving beyond traditional inhalation techniques to new organic prodrugs that can release CO in a controlled manner. By using experimental colitis models in mice, the research seeks to understand how CO can reduce inflammation and promote healing in the intestines. Patients may benefit from advancements in treatment options for inflammatory bowel diseases if these methods prove successful.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory bowel diseases, such as colitis.
Not a fit: Patients with non-inflammatory gastrointestinal disorders or those who do not respond to anti-inflammatory treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for inflammatory bowel diseases, improving patient outcomes and quality of life.
How similar studies have performed: Previous studies have shown promising results using carbon monoxide in various inflammatory models, indicating potential for success in this novel application.
Where this research is happening
Atlanta, United States
- Georgia State University — Atlanta, United States (Active)
Researchers
- Principal investigator: Wang, Binghe — Georgia State University
- Study coordinator: Wang, Binghe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.