Using brainwave patterns to tailor mental health treatments
Evaluating the potential of neural oscillation biomarkers in a rodent model of intervention outcome variation: Toward personalized mental health care
['FUNDING_R01'] · DARTMOUTH-HITCHCOCK CLINIC · NIH-11094925
Researchers are seeing if brainwave patterns can help predict which treatments will work best for people with ADHD or borderline personality disorder.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH-HITCHCOCK CLINIC (nih funded) |
| Locations | 1 site (LEBANON, UNITED STATES) |
| Trial ID | NIH-11094925 on ClinicalTrials.gov |
What this research studies
Scientists are studying outbred rats that show different decision-making behaviors to model the variety seen in people with ADHD and borderline personality disorder. They will record neural oscillations (brainwave patterns) while the rats perform delay- and risk-discounting tasks and apply brain stimulation, drugs, or chemogenetic manipulation. The team will look for patterns that predict which individuals show benefit or harm from each intervention across sexes. This proof-of-concept work aims to identify biomarkers that could later guide personalized treatment choices in humans.
Who could benefit from this research
Good fit: People diagnosed with ADHD or borderline personality disorder who are interested in future personalized treatment options would be the eventual target population.
Not a fit: Because the current work is done in animals and is early-stage, patients should not expect direct or immediate treatment benefits from this grant.
Why it matters
Potential benefit: If successful, this work could lead to brainwave biomarkers that help clinicians choose more effective, personalized treatments for ADHD and borderline personality disorder.
How similar studies have performed: Related animal studies and preliminary data show behavioral variation and some promising signals, but comparable biomarker-guided treatment approaches are not yet proven in people.
Where this research is happening
LEBANON, UNITED STATES
- DARTMOUTH-HITCHCOCK CLINIC — LEBANON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOUCETTE, WILDER T — DARTMOUTH-HITCHCOCK CLINIC
- Study coordinator: DOUCETTE, WILDER T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Attention deficit hyperactivity disorder, Borderline Personality Disorder