Using blood tests to track nerve damage in multiple sclerosis
Validation of Serum Neurofilament Light Chain as a Prognostic and Monitoring Biomarker in Multiple Sclerosis
This study is looking at a blood test that measures a substance called sNfL to help track nerve damage in people with multiple sclerosis, so doctors can catch any problems earlier and take action to prevent long-term issues.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10774227 on NIH RePORTER |
What this research studies
This research investigates the use of serum neurofilament light chain (sNfL) as a biomarker to monitor nerve damage in patients with multiple sclerosis (MS). By analyzing blood samples, the study aims to identify ongoing neuro-axonal injury that may not be visible through traditional MRI scans. This approach seeks to provide earlier insights into disease progression, allowing for timely interventions to prevent permanent disability. The research will involve comparing sNfL levels with clinical evaluations and MRI findings to establish its effectiveness as a monitoring tool.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who are experiencing symptoms or have concerns about disease progression.
Not a fit: Patients with other neurological disorders that do not involve neuro-axonal injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and management of multiple sclerosis, potentially reducing the risk of long-term disability for patients.
How similar studies have performed: Previous studies have shown promising results using neurofilament levels as biomarkers in various neurological conditions, indicating a potential for success in this novel application for multiple sclerosis.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Calabresi, Peter a — Johns Hopkins University
- Study coordinator: Calabresi, Peter a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.