Using biomarkers to personalize treatment for alcohol use disorder and PTSD
Leveraging biomarkers for personalized treatment of alcohol use disorder comorbid with PTSD
This study is looking to help people who struggle with both alcohol use and PTSD by finding out how certain biological markers can guide personalized treatment, especially using the medication topiramate, so that each person can get the best care for their unique needs.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10473674 on NIH RePORTER |
What this research studies
This research aims to improve treatment for individuals with alcohol use disorder (AUD) who also suffer from post-traumatic stress disorder (PTSD) by utilizing biomarkers. The study will investigate how specific molecular and circuit biomarkers can inform personalized treatment approaches, particularly focusing on the medication topiramate. Researchers will analyze brain and plasma markers in both animal models and clinical trial participants to understand the neurobiological mechanisms involved. By integrating various methodologies, including EEG and MRI, the research seeks to identify effective treatment strategies tailored to individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol use disorder who also have a comorbid diagnosis of PTSD.
Not a fit: Patients who do not have alcohol use disorder or PTSD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatment options for patients struggling with both alcohol use disorder and PTSD.
How similar studies have performed: Previous research has shown promise in using biomarkers for personalized treatment in various mental health conditions, suggesting potential success for this approach.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Marmar, Charles R. — New York University School of Medicine
- Study coordinator: Marmar, Charles R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.