Using advanced imaging to improve treatment for brain cancer
Utilization of Immuno-PET to detect response and guide novel oHSV-based therapy for glioma
This study is looking at how new imaging technology can help us see how your immune system responds to a special treatment for glioblastoma, a type of brain cancer, using a modified virus, so we can find better ways to help you and others with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11061267 on NIH RePORTER |
What this research studies
This research investigates how advanced imaging techniques can track the immune response in patients with glioblastoma, a type of brain cancer, during a novel therapy using oncolytic herpes simplex virus (oHSV). By utilizing immuno-PET imaging, the study aims to measure how T-cells are activated and infiltrate tumors over time, providing insights that could enhance treatment effectiveness. The goal is to better understand the immune changes that occur during therapy, which could lead to improved patient selection and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are considering or undergoing immunotherapy treatments.
Not a fit: Patients with other types of brain tumors or those not eligible for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment plans for patients with glioblastoma by allowing for earlier and more accurate assessments of their response to therapy.
How similar studies have performed: Other research has shown promising results using advanced imaging techniques in cancer treatment, suggesting that this approach could be a significant advancement in the field.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Sorace, Anna C — University of Alabama at Birmingham
- Study coordinator: Sorace, Anna C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.