Using advanced imaging to improve diagnosis of anal lesions in people with HIV
The Effectiveness of Automated Multimodal Imaging in High Grade Squamous Intraepithelial Lesions (HSIL) Diagnosis for People Living with HIV: An International Trial
This study is testing a new, easy-to-use imaging tool that helps doctors quickly and accurately spot abnormal areas in people with HIV, making it easier to diagnose and treat potential anal cancer without the need for painful biopsies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11017535 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of a novel, low-cost imaging technique called Mobile High-Resolution Micro-Endoscope (HRME) for diagnosing high-grade squamous intraepithelial lesions (HSIL) in individuals living with HIV. The approach aims to provide real-time 'optical biopsies' that can accurately identify abnormal areas without the need for invasive procedures like traditional biopsies. By streamlining the diagnosis and treatment process, this study seeks to reduce patient discomfort and improve follow-up rates, especially in diverse healthcare settings. The ultimate goal is to enhance screening and treatment for anal cancer, which is increasingly prevalent among this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are at risk for high-grade squamous intraepithelial lesions or anal cancer.
Not a fit: Patients who do not have HIV or those without any risk factors for anal lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and less invasive diagnostic methods for anal lesions, significantly improving patient care for those living with HIV.
How similar studies have performed: Previous studies have shown promise in using advanced imaging techniques for cancer diagnosis, indicating that this approach could be effective, although the specific application of HRME in this context is relatively novel.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Anandasabapathy, Sharmila — Baylor College of Medicine
- Study coordinator: Anandasabapathy, Sharmila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.