Using advanced genetic techniques to study blood vessel growth and scarring in diseases.
A CRISPR-based modular transgenic system to advance in vivo investigations of angiogenesis and fibrosis
This study is using special mice to help scientists learn more about how blood vessels grow and how scarring happens in diseases like heart disease and cancer, which could lead to better treatments for people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10693065 on NIH RePORTER |
What this research studies
This research focuses on creating specialized mice that can help scientists understand how blood vessels grow and how scarring occurs in various diseases. By using advanced genetic tools, the researchers aim to track specific cells involved in these processes, which can provide insights into conditions like heart disease and cancer. The study will utilize a method that allows for precise manipulation of genes in these mice, enabling researchers to observe the effects of specific cell behaviors on disease progression. This approach could lead to a better understanding of how to treat or prevent these conditions in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to abnormal blood vessel growth or fibrosis, such as atherosclerosis or certain types of cancer.
Not a fit: Patients with conditions unrelated to blood vessel growth or fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases characterized by abnormal blood vessel growth and scarring.
How similar studies have performed: Previous research using similar genetic techniques has shown promise in understanding cell behavior in various diseases, indicating a potential for success in this approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Wolf, Matthew J — University of Virginia
- Study coordinator: Wolf, Matthew J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.