Using advanced gene editing to create precise cancer models in mice
Official title: In vivo prime editing for precision cancer mouse models
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10909321 · Data updated 2026-11-12
This study is exploring a new way to edit genes in mice to better understand cancer by creating models that mimic real cancer mutations, which could help researchers find better treatments and tests for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | August 17, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $594,327 |
| NIH project number | 5R01CA275945-02 |
| Project ID | NIH-10909321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with specific cancer mutations that are being studied in the mouse models.
✕Less likely to help
Patients without identifiable cancer mutations or those not involved in the specific types of cancer being modeled may not benefit from this research.
What this research studies
This research focuses on developing a new gene editing technique called prime editing to create accurate mouse models of cancer. By using this method, researchers aim to replicate various cancer mutations directly in adult mouse tissues, which can help in understanding how these mutations contribute to tumor growth and treatment resistance. The approach allows for rapid and flexible modeling of cancer, potentially leading to better interventions and biomarkers for patients. The study seeks to optimize this technique to improve the efficiency of generating these models.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments and personalized medicine approaches for patients.
How similar studies have gone: Other research has shown promise with CRISPR-based approaches, but prime editing is a newer and less tested method in this context.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Xue, Wen — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Xue, Wen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.