Understanding why Black and White patients experience different rates of heart disease and heart failure.

REasons for Geographic And Racial Differences in Stroke-Myocardial Infarction-4 (REGARDS-MI-4)

['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11081894

This study is looking at why Black and White people in the U.S. experience heart disease and heart failure differently, focusing on how social factors and racism play a role, and it aims to help researchers understand these issues better while also supporting new scientists from diverse backgrounds.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorWEILL MEDICAL COLL OF CORNELL UNIV (nih funded)
Locations1 site (NEW YORK, UNITED STATES)
Trial IDNIH-11081894 on ClinicalTrials.gov

What this research studies

This research investigates the persistent disparities in coronary heart disease (CHD) and heart failure (HF) between Black and White populations in the U.S. It focuses on how social determinants of health, including structural racism, impact these disparities over a person's lifetime. By examining both the incidence and recurrence of heart conditions, the study aims to uncover the underlying mechanisms that contribute to these differences. The research will also provide valuable data on heart disease events and causes of death, which can be utilized by other investigators. Additionally, it includes a career development program for early-stage investigators, particularly those from underrepresented backgrounds.

Who could benefit from this research

Good fit: Ideal candidates for this research include Black and White adults who are at risk for or have been diagnosed with coronary heart disease or heart failure.

Not a fit: Patients who do not identify as Black or White or those without risk factors for heart disease may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and interventions that reduce heart disease disparities among different racial groups.

How similar studies have performed: Previous research has shown that addressing social determinants of health can lead to meaningful improvements in health outcomes, suggesting that this approach may yield significant insights.

Where this research is happening

NEW YORK, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: Cardiac Diseases, Cardiac Disorders, Coronary Disease

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.