Understanding why autoimmune diseases become long-lasting
Mediators of chronicity in autoimmune endocrinopathies.
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11190802
This research explores why autoimmune conditions like Type 1 Diabetes cause lasting damage, hoping to find new ways to stop them from getting worse.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11190802 on ClinicalTrials.gov |
What this research studies
Many autoimmune conditions, such as Type 1 Diabetes, cause permanent damage and require lifelong treatment because the body's immune system keeps attacking its own tissues. This project aims to uncover the specific genetic and cellular changes that make these diseases chronic instead of resolving. We want to understand how certain immune cells continue to renew themselves and become harmful, focusing on a key regulator called UTX. By studying these processes, we hope to find new targets for treatments that could prevent or reverse the long-term effects of these conditions.
Who could benefit from this research
Good fit: Patients with autoimmune endocrinopathies, such as Type 1 Diabetes, who experience chronic disease progression might be ideal candidates for future related studies.
Not a fit: Patients whose autoimmune conditions are not chronic or do not involve the specific cellular mechanisms being studied may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent the ongoing damage in autoimmune diseases like Type 1 Diabetes, potentially reducing the need for lifelong hormone replacement.
How similar studies have performed: While the specific mechanisms being explored are novel, preliminary data in mouse models suggest a role for the epigenetic regulator UTX, indicating a promising direction for this approach.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUTTE, MANISH J — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: BUTTE, MANISH J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diabetes, Autoimmune Diseases