Understanding weight loss in obese patients with end-stage kidney disease
Official title: Identifying Healthy and High-Risk Weight Loss Phenotypes to Optimize Obesity Management in End Stage Kidney Disease
Funded at Drexel University · NIH-10861854 · Data updated 2026-11-12
This study is looking at how losing weight can impact people with end-stage kidney disease who are also obese, to help find safer ways to manage their weight and improve their health while they’re on dialysis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $290,880 |
| NIH project number | 5R01DK124388-05 |
| Project ID | NIH-10861854 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are obese individuals with end-stage kidney disease who are undergoing dialysis treatment.
✕Less likely to help
Patients who are not obese or those who do not have end-stage kidney disease may not benefit from this research.
What this research studies
This research investigates how weight loss affects patients with end-stage kidney disease, particularly those who are obese. It aims to identify different types of weight loss—healthy versus high-risk—among these patients, as they often experience weight changes after starting dialysis. The study will analyze factors like muscle loss and nutrition to develop better guidelines for managing obesity in this population. By understanding these weight loss phenotypes, the research seeks to improve treatment strategies for patients undergoing dialysis.
Why it matters
Potential benefit: If successful, this research could lead to tailored weight management strategies that improve health outcomes for obese patients with end-stage kidney disease.
How similar studies have gone: While there is ongoing research in obesity management, this specific approach to differentiating weight loss phenotypes in dialysis patients is novel and has not been extensively tested.
Where this research is happening
-
Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Harhay, Meera Nair — Drexel University
- Study coordinator: Harhay, Meera Nair
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.