Understanding urinary stone disease and its causes
Research Project
This study is looking into how urinary stones form in the body and how they cause inflammation, with the goal of finding new ways to prevent and treat this painful condition for anyone who suffers from it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10839868 on NIH RePORTER |
What this research studies
This research investigates urinary stone disease (USD), which is a common condition affecting both men and women. It aims to understand the mechanisms behind the formation of urinary stones by studying how certain crystals interact with kidney cells and the immune response. The researchers will analyze how these interactions lead to inflammation and the development of stones, using both laboratory studies and animal models. By identifying specific biomarkers and cellular responses, the research seeks to uncover new ways to prevent and treat this painful condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have a history of urinary stone formation or are at risk for developing urinary stones.
Not a fit: Patients who do not have urinary stone disease or related risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for urinary stone disease, reducing pain and healthcare costs for patients.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of urinary stone formation, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lieske, John C — Mayo Clinic Rochester
- Study coordinator: Lieske, John C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.