NIH-funded research NIH-funded research

Understanding the variety of microbes in the human gut

Official title: Decoding Microbial Diversity in the Human Gut Microbiome

Funded at Pennsylvania State University, the · NIH-11095887 · Data updated 2026-11-12

This study is looking at how different types of gut bacteria can impact our health, using special tests and computer analysis to understand their effects better, and it's for anyone interested in how our gut health can influence our overall well-being.

More Gut Microbiome research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionPennsylvania State University, the
NIH-funded
Lab location1 site (University Park, United States)
Project startAugust 1, 2023
Project endMay 31, 2028
Funding year2025
Award (this year)$377,103
NIH project number5R35GM151045-03
Project IDNIH-11095887 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals with gastrointestinal conditions or those interested in understanding their gut health.

Less likely to help

Patients with no gastrointestinal issues or those not interested in microbiome research may not benefit from this research.

What this research studies

This research investigates how different strains of microbes in the human gut affect health and physiology. By using advanced sequencing technologies and computational biology, the team aims to uncover the relationships between microbial diversity and various health outcomes. The approach includes both laboratory experiments with specially designed animal models and analysis of large datasets to identify key microbial genes. This work seeks to provide insights into how our gut microbiome influences our overall well-being.

Why it matters

Potential benefit: If successful, this research could lead to new strategies for improving gut health and treating related diseases.

How similar studies have gone: Previous research has shown promising results in understanding gut microbiome diversity, but this approach aims to provide deeper mechanistic insights that are less explored.

Where this research is happening

  • Pennsylvania State University, the
    University Park, United States
    Active

Researchers

  • Principal investigator: Bisanz, Jordan Adam — Pennsylvania State University, the
  • Study coordinator: Bisanz, Jordan Adam

Related research

Other NIH-funded projects on the same topics.

  • Multi-agent AI to annotate enzymes in the human gut microbiome

    A team at a major university will build an AI system that automatically curates and labels the functions of enzymes in the human gut microbiome to speed up understanding their health effects.

    NIH research University of South Florida · Tampa, United States · NIH-11594384

  • Mapping how gut bacteria transform drugs

    Scientists will study how the gut microbiome changes thousands of drugs into new forms, which could affect how well a medicine works or whether it causes side effects.

    NIH research Stanford University · Stanford, United States · NIH-11550022

  • Aflatoxin exposure and child growth in Guatemala

    A study in rural Guatemala will track how exposure to aflatoxin relates to growth and gut health in young children.

    NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11513260

  • Gut bacteria that can make cancer immunotherapy less effective

    This project will see if reducing chronic inflammation driven by certain gut bacteria can help immunotherapy work better for people whose cancers have stopped responding.

    NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11478145

  • How gut bacteria affect how cancer drugs work

    This project looks at how the bacteria in your gut might change how well and with what side effects fluoropyrimidine cancer drugs like 5-FU work in people.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11473234

  • Gut bacteria and cancer drugs: how your gut may change chemotherapy effectiveness

    This project studies how the gut microbiome might affect how well certain chemotherapy drugs work and their side effects in people with cancer.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11473233

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.