Understanding the roles of specific immune cells in autoimmune diseases
Dissecting functions of IL-23-dependent inflammatory Th17 cells
This study is looking at a type of immune cell called Th17, which can sometimes help fight infections but can also cause problems in autoimmune diseases, to find out how we can better treat these conditions by focusing on the good and bad sides of these cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10746015 on NIH RePORTER |
What this research studies
This research investigates the different functions of inflammatory Th17 cells, which play a significant role in autoimmune diseases. By distinguishing between the beneficial and harmful effects of these cells, the study aims to understand how they can be targeted for more effective treatments. The researchers will analyze metabolic differences between autoimmune and anti-infection Th17 cells using both mouse models and samples from human patients. This approach could lead to the development of new therapies that selectively inhibit harmful immune responses while preserving protective functions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autoimmune diseases who may benefit from targeted therapies.
Not a fit: Patients with non-autoimmune conditions or those not producing inflammatory Th17 cells may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for autoimmune diseases.
How similar studies have performed: Previous research has shown promise in targeting specific immune cell functions, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: He, Zhiheng — University of Southern California
- Study coordinator: He, Zhiheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.