Understanding the role of specific immune cells in Type 1 Diabetes
Specificity, Phenotype and Function of Pancreatic CD8 T Cells in Human Type 1 Diabetes
This study is looking at how certain immune cells called CD8 T cells attack the insulin-producing cells in people with Type 1 Diabetes, using samples from organ donors to learn more about how these cells behave and could help find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11041467 on NIH RePORTER |
What this research studies
This research investigates how CD8 T cells contribute to the destruction of insulin-producing cells in individuals with Type 1 Diabetes (T1D). By analyzing samples from organ donors, the study aims to identify the characteristics and functions of these immune cells, which are believed to play a key role in the disease. The researchers will use advanced techniques to track and quantify these cells within the pancreas, providing insights into their behavior during the progression of T1D. This work could lead to a better understanding of the autoimmune processes involved in T1D and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes, particularly those experiencing early stages of the disease.
Not a fit: Patients with Type 2 Diabetes or other forms of diabetes unrelated to autoimmune processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or preventive strategies for individuals with Type 1 Diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in Type 1 Diabetes, indicating that this approach has potential for significant findings.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Quesada Masachs, Estefania — University of Miami School of Medicine
- Study coordinator: Quesada Masachs, Estefania
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.