Understanding the role of specific immune cells in Type 1 Diabetes
Official title: Specificity, Phenotype and Function of Pancreatic CD8 T Cells in Human Type 1 Diabetes
Funded at University of Miami School of Medicine · NIH-11041467 · Data updated 2026-11-12
This study is looking at how certain immune cells called CD8 T cells attack the insulin-producing cells in people with Type 1 Diabetes, using samples from organ donors to learn more about how these cells behave and could help find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $460,500 |
| NIH project number | 7R01AI092453-12 |
| Project ID | NIH-11041467 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes, particularly those experiencing early stages of the disease.
✕Less likely to help
Patients with Type 2 Diabetes or other forms of diabetes unrelated to autoimmune processes may not benefit from this research.
What this research studies
This research investigates how CD8 T cells contribute to the destruction of insulin-producing cells in individuals with Type 1 Diabetes (T1D). By analyzing samples from organ donors, the study aims to identify the characteristics and functions of these immune cells, which are believed to play a key role in the disease. The researchers will use advanced techniques to track and quantify these cells within the pancreas, providing insights into their behavior during the progression of T1D. This work could lead to a better understanding of the autoimmune processes involved in T1D and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or preventive strategies for individuals with Type 1 Diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune cells in Type 1 Diabetes, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Quesada Masachs, Estefania — University of Miami School of Medicine
- Study coordinator: Quesada Masachs, Estefania
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.