Understanding the role of NMDA receptors in brain communication
Molecular and functional diversity of NMDA receptors in the thalamus
['FUNDING_R01'] · VIRGINIA POLYTECHNIC INST AND ST UNIV · NIH-10593091
This study looks at how the brain's communication between two areas affects our thoughts and feelings, especially in conditions like epilepsy and mental health issues, to find new ways to help improve treatments for these challenges.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA POLYTECHNIC INST AND ST UNIV (nih funded) |
| Locations | 1 site (BLACKSBURG, UNITED STATES) |
| Trial ID | NIH-10593091 on ClinicalTrials.gov |
What this research studies
This research investigates how communication between the cortex and thalamus affects thoughts, emotions, and sensations. It focuses on the balance of excitation and inhibition in the thalamus, which can be disrupted in conditions like epilepsy and psychiatric disorders. By examining the synaptic physiology and the specific glutamate receptor subtypes involved, the research aims to identify potential targets for new treatments. Patients may benefit from insights that could lead to improved therapies for various neurological and psychiatric conditions.
Who could benefit from this research
Good fit: Ideal candidates include individuals with epilepsy, psychiatric disorders, or movement disorders who experience disruptions in perception, movement, or emotional regulation.
Not a fit: Patients with conditions unrelated to thalamic dysfunction or those not experiencing neurological or psychiatric symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for epilepsy and psychiatric disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of NMDA receptors in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
BLACKSBURG, UNITED STATES
- VIRGINIA POLYTECHNIC INST AND ST UNIV — BLACKSBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWANGER, SHARON ANN — VIRGINIA POLYTECHNIC INST AND ST UNIV
- Study coordinator: SWANGER, SHARON ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental disorders, Mental health disorders, Psychiatric Disease, Psychiatric Disorder, psychological disorder