Understanding the outer layers of the bacteria that cause tooth decay
MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
This project looks at how proteins are built into the outer layers of a common mouth bacteria called Streptococcus mutans, which causes cavities and can also lead to heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11128351 on NIH RePORTER |
What this research studies
Streptococcus mutans is a common bacteria in our mouths that causes tooth decay and can sometimes lead to serious heart infections. This project aims to understand how this bacteria builds its outer membrane, which is crucial for its survival and ability to cause disease. By learning more about how these membrane proteins are put together, we hope to find new ways to stop the bacteria from causing harm. This work could lead to new treatments that specifically target these bacteria, helping to prevent cavities and other related health issues.
Who could benefit from this research
Good fit: Patients who suffer from frequent dental cavities or are at risk for bacterial endocarditis might eventually benefit from this research.
Not a fit: Patients whose conditions are not related to Streptococcus mutans infections would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new targeted treatments to prevent tooth decay and serious heart infections caused by Streptococcus mutans.
How similar studies have performed: While the general mechanisms of protein transport are known, this project focuses on unique properties within S. mutans to develop targeted therapies, making its specific application novel.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Brady, L. Jeannine — University of Florida
- Study coordinator: Brady, L. Jeannine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.