Understanding the genetics of obsessive-compulsive disorder in Latin American communities
Official title: Genomics of OCD in Latin American Communities
Funded at Icahn School of Medicine at Mount Sinai · NIH-10884430 · Data updated 2026-11-12
This study is looking at how different genes might affect the chances of developing obsessive-compulsive disorder (OCD), especially in people from Latin American backgrounds, and it invites patients to help by sharing their genetic information to find new ways to treat OCD.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 7, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $126,090 |
| NIH project number | 5K99MH128540-02 |
| Project ID | NIH-10884430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals of Latin American descent who have been diagnosed with obsessive-compulsive disorder.
✕Less likely to help
Patients who do not have OCD or those from populations not represented in the study may not receive any benefit from this research.
What this research studies
This research investigates how both common and rare genetic variations contribute to the risk of developing obsessive-compulsive disorder (OCD), particularly focusing on Latin American populations. By utilizing advanced techniques such as genome-wide association studies and whole exome sequencing, the study aims to identify genetic risk factors that have been overlooked in previous research primarily focused on European ancestry. The project seeks to increase the sample size of OCD cases and apply multi-omic approaches to uncover the genetic architecture of OCD, which could lead to new treatment options. Patients may be involved in the collection of genetic samples and data to help advance our understanding of this disorder.
Why it matters
Potential benefit: If successful, this research could lead to the identification of genetic markers for OCD, paving the way for targeted therapies and improved treatment strategies.
How similar studies have gone: Previous research in other neurodevelopmental disorders has shown success in identifying genetic risk factors using similar methodologies, suggesting a promising approach for OCD as well.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Cappi, Carolina — Icahn School of Medicine at Mount Sinai
- Study coordinator: Cappi, Carolina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.