Understanding the genetics of acute respiratory distress syndrome (ARDS)
Official title: Tissue-specific functional genomics in the acute respiratory distress syndrome
Funded at Vanderbilt University Medical Center · NIH-11061058 · Data updated 2026-11-12
This study is looking at how our genes might affect how people with acute respiratory distress syndrome (ARDS) respond to the condition, so we can better understand it and find more effective treatments for those who are critically ill.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $169,102 |
| NIH project number | 5K01HL157755-05 |
| Project ID | NIH-11061058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill adults who have been diagnosed with acute respiratory distress syndrome.
✕Less likely to help
Patients who do not have ARDS or are under 21 years old may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to acute respiratory distress syndrome (ARDS), a serious condition affecting many adults. By analyzing large-scale electronic health records and DNA samples, the study aims to identify specific genetic variations that influence how patients respond to ARDS. The research will focus on gene expression in lung tissues and immune cells from critically ill adults, helping to categorize different subtypes of ARDS. This approach could lead to better predictions of disease risk and the development of targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options for patients with ARDS, improving their chances of recovery.
How similar studies have gone: Previous research has shown promise in using genetic analysis to understand complex diseases, indicating that this approach could yield valuable insights for ARDS.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Kerchberger, Vern Eric — Vanderbilt University Medical Center
- Study coordinator: Kerchberger, Vern Eric
Related research
Other NIH-funded projects on the same topics.
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Identifying ARDS patients who may benefit from paralytics guided by high-frequency clinical data
This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
-
Resilience endotypes and early ARDS detection using biomarkers and AI
A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
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PAR1’s role in lung lymphatics and a new therapy approach for ARDS
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
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Dead space and inhaled nitric oxide in pediatric ARDS
This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
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Immune, hormone, and muscle energy links to recovery after ARDS
This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.