Understanding the genetics behind carotid artery disease progression in patients who haven't improved with non-surgical treatments
Official title: Genetics of carotid artery disease progression among patients who have failed non-operative management
Funded at Massachusetts General Hospital · NIH-10899231 · Data updated 2026-11-12
This study is looking at how your genes might affect the worsening of carotid artery disease in people who haven't improved with other treatments, to help identify those at greater risk for serious issues like strokes, so we can better decide who might need surgery.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $92,756 |
| NIH project number | 1F32HL174327-01 |
| Project ID | NIH-10899231 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with carotid artery stenosis who have not improved with non-surgical treatments.
✕Less likely to help
Patients with carotid artery disease who have already undergone surgical intervention or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to the progression of carotid artery stenosis (CAS) in patients who have not responded to non-operative management. By comparing the genetic profiles of patients with asymptomatic and symptomatic CAS, the study aims to identify specific genetic markers that could help predict which patients are at higher risk for severe complications, such as ischemic stroke. The approach involves conducting genome-wide association studies (GWAS) to analyze a large cohort of patients, which may lead to better patient stratification for surgical interventions. This research seeks to enhance our understanding of how genetics influences the severity of carotid artery disease.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying patients who would benefit from early surgical intervention, potentially reducing the risk of stroke.
How similar studies have gone: Previous genetic studies in related atherosclerotic diseases have shown promise, suggesting that this approach could yield valuable insights into carotid artery disease as well.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Bellomo, Tiffany — Massachusetts General Hospital
- Study coordinator: Bellomo, Tiffany
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.