Understanding the Genetic Roots of Psychiatric Conditions
Statistical methods to localize disease heritability and identify biological mechanisms
This project aims to find more of the hidden genetic factors that contribute to conditions like autism, ADHD, and bipolar disorder, helping us understand how they work.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11092881 on NIH RePORTER |
What this research studies
We know that genetics play a role in conditions like schizophrenia, autism, and bipolar disorder, but many genetic influences are still unknown. This project uses advanced statistical tools to uncover these missing genetic links by looking at both common and rare genetic variations. We will use information from over 800,000 genetic samples from people with psychiatric conditions to better understand the biological processes involved. The goal is to develop new methods that can pinpoint specific genetic areas and how they contribute to these disorders.
Who could benefit from this research
Good fit: This foundational research uses existing genetic data from people with conditions like schizophrenia, autism, ADHD, and bipolar disorder.
Not a fit: Patients not interested in the genetic underpinnings of psychiatric disorders or those without these specific conditions may not find direct benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to a much clearer understanding of the genetic and biological causes of psychiatric disorders, paving the way for new ways to prevent or treat them.
How similar studies have performed: While genetic studies have successfully identified some links, this project aims to develop novel statistical methods to uncover the vast majority of genetic effects that are currently undetected.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Neale, Benjamin Michael — Broad Institute, INC.
- Study coordinator: Neale, Benjamin Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.