Understanding the genetic makeup of moles and their link to melanoma
Molecular basis of melanocytic nevi
This study is looking at the genes in moles to see how they might help us tell the difference between harmless moles and those that could turn into melanoma, which is a serious skin cancer, so we can improve how we diagnose and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10683365 on NIH RePORTER |
What this research studies
This research investigates the genetic characteristics of melanocytic nevi, commonly known as moles, to better understand their role as potential precursors to melanoma, a serious form of skin cancer. The study aims to identify specific genetic mutations that differentiate benign moles from malignant melanoma, which could lead to improved diagnostic methods. By analyzing the genomic landscape of these nevi, researchers hope to establish novel markers that can aid in accurate diagnosis and treatment strategies. This work is particularly important as current diagnostic methods can be inconsistent among pathologists.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with multiple moles or those who have had moles biopsied for evaluation.
Not a fit: Patients with no history of moles or skin lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses of skin lesions, potentially reducing the incidence of misdiagnosed melanoma.
How similar studies have performed: Previous research has shown promise in identifying genetic markers in melanoma, suggesting that similar approaches for nevi may also yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Kiuru, Maija Helena Tuulia — University of California at Davis
- Study coordinator: Kiuru, Maija Helena Tuulia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.