Understanding the genetic factors in type 1 diabetes
Official title: Characterizing Immunogenetics in Type 1 Diabetes
Funded at Fred Hutchinson Cancer Center · NIH-11046646 · Data updated 2026-11-12
This study is looking at how certain genes might affect the start and progression of type 1 diabetes, with the hope of finding new ways to improve screening, diagnosis, and treatment for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $564,946 |
| NIH project number | 5R01DK132406-03 |
| Project ID | NIH-11046646 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of type 1 diabetes or those who have shown early signs of autoimmune activity related to the disease.
✕Less likely to help
Patients who are already diagnosed with advanced type 1 diabetes may not benefit from this research.
What this research studies
This research investigates the genetic mechanisms that contribute to the onset and progression of type 1 diabetes mellitus (T1DM). By focusing on specific genetic segments within the HLA/KIR/FcGR/IGHG genes, the study aims to identify novel regulatory elements that influence disease progression. Utilizing advanced genetic sequencing techniques, the researchers will analyze genetic variations that may not be captured by traditional methods. The ultimate goal is to develop better screening, diagnostic, preventive, and treatment strategies for T1DM.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for preventing or delaying the onset of type 1 diabetes in at-risk individuals.
How similar studies have gone: Previous studies have shown promise in identifying genetic markers associated with type 1 diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Zhao, Lue Ping — Fred Hutchinson Cancer Center
- Study coordinator: Zhao, Lue Ping
Related research
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This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.