Understanding the genetic factors behind coronary artery disease
Multimodal genetic regulatory architecture of coronary artery disease
This study is looking at how our genes and cells might play a role in coronary artery disease (CAD) by examining heart tissue from different people, with the goal of finding new ways to understand and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10980582 on NIH RePORTER |
What this research studies
This research investigates the genetic and regulatory mechanisms that contribute to coronary artery disease (CAD) by analyzing genetic variations in coronary tissues from diverse populations. Using advanced techniques like single-cell genomics, the study aims to identify specific genes and cell types involved in the disease process. By profiling both healthy and diseased tissues, researchers hope to uncover how certain cells transition and contribute to CAD. This comprehensive approach could lead to a better understanding of the disease and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of coronary artery disease or those diagnosed with early-stage atherosclerosis.
Not a fit: Patients with advanced coronary artery disease or those who do not have genetic predispositions to CAD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for coronary artery disease, ultimately enhancing patient outcomes.
How similar studies have performed: Other research has shown success in using genetic profiling to understand coronary artery disease, making this approach promising yet still innovative.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Miller, Clint L — University of Virginia
- Study coordinator: Miller, Clint L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.