Understanding the genetic causes of inflammatory bowel disease
Identification and characterization of inflammatory bowel disease causal variants
This study is looking at how our genes might play a role in inflammatory bowel diseases (IBD) in teens and young adults, and it invites patients to help by sharing genetic samples so we can better understand what causes these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10849793 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to inflammatory bowel diseases (IBD), which are chronic conditions affecting the gastrointestinal tract, particularly in adolescents and young adults. By analyzing a diverse cohort of patients from different ancestral backgrounds, the study aims to identify specific genetic variants associated with IBD and understand their functional impacts. The research employs advanced techniques, including genome-wide association studies and CRISPR-based methods, to explore how these genetic variants influence the disease. Patients may be involved in providing genetic samples to help elucidate these connections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with inflammatory bowel disease, particularly those from diverse ancestral backgrounds.
Not a fit: Patients with non-inflammatory bowel diseases or those without a genetic predisposition to IBD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and targeted treatments for inflammatory bowel disease, improving patient outcomes.
How similar studies have performed: Previous studies have successfully identified genetic variants associated with IBD, but this research aims to expand on that by including diverse populations, making it a novel approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Huang, Hailiang — Massachusetts General Hospital
- Study coordinator: Huang, Hailiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.