Understanding the genetic and physical differences in cerebral palsy
Official title: Characterizing the spectrum of genomic and phenotypic variation in cerebral palsy
Funded at Geisinger Clinic · NIH-10896426 · Data updated 2026-11-12
This study is looking at how genes and physical traits are linked to cerebral palsy, and it's for people of all ages with the condition, as it aims to find out more about what causes CP and how to help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Geisinger Clinic NIH-funded |
| Lab location | 1 site (Danville, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $666,187 |
| NIH project number | 5R01HD104938-03 |
| Project ID | NIH-10896426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cerebral palsy, both children and adults, who are willing to participate in genetic testing and neuroimaging.
✕Less likely to help
Patients with cerebral palsy who do not have a genetic component to their condition or those who are unable to participate in genetic testing may not benefit from this research.
What this research studies
This research investigates the genetic and phenotypic variations associated with cerebral palsy (CP), a developmental brain disorder. By analyzing data from both pediatric and adult cohorts, the study aims to identify rare and common genomic variants that contribute to CP. Patients will undergo genetic testing and neuroimaging to explore the relationship between their genetic makeup and the physical manifestations of the disorder. This comprehensive approach seeks to clarify the underlying causes of CP and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of cerebral palsy, potentially improving treatment options and outcomes for affected individuals.
How similar studies have gone: Other research has shown success in identifying genetic factors in similar developmental brain disorders, suggesting that this approach could yield valuable insights for cerebral palsy as well.
Where this research is happening
-
Geisinger Clinic
Danville, United States Active
Researchers
- Principal investigator: Myers, Scott — Geisinger Clinic
- Study coordinator: Myers, Scott
Related research
Other NIH-funded projects on the same topics.
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Measuring how kids with cerebral palsy adapt their walking
A study to understand how children with cerebral palsy learn and adjust walking, and how personalized feedback during walking might improve their mobility.
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Precise measure of how CP affects movement to guide treatment
Aims to create precise, child-friendly ways to measure selective motor control in cerebral palsy so treatment can be tailored to each child.
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Non-invasive spinal stimulation to help kids with cerebral palsy move and reduce stiffness
This study tests a non-invasive spinal stimulation plus treadmill training to reduce spasticity and improve walking in children with cerebral palsy.
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Physiologic marker to predict cerebral palsy early in high-risk babies
Aims to create an early, easy screen using NICU vital signs to flag infants at higher risk for cerebral palsy so families can get timely follow-up.
-
Post-surgical foot deformities in adults with cerebral palsy: understanding long-term function
This research looks at how hindfoot problems in adults with cerebral palsy behave over time after childhood surgeries and what factors influence their lasting function.
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Dynamic Brain Imaging of Cerebral Palsy Gait
This project uses advanced brain and spinal imaging to understand how cerebral palsy affects the way young people plan and control their leg movements during walking.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.