Understanding the functions of noncoding genetic elements in living organisms
Official title: In vivo functional screen of noncoding genetic elements
Funded at Northwestern University at Chicago · NIH-11031383 · Data updated 2026-11-12
This study is looking at the parts of our DNA that don’t code for proteins, which make up most of our genetic material, to see how they influence important processes in living animals, with the hope of learning more about conditions like cancer and brain development issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $224,101 |
| NIH project number | 5R00HG012593-04 |
| Project ID | NIH-11031383 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases that may be influenced by noncoding genomic elements.
✕Less likely to help
Patients with conditions unrelated to genetic factors or those who do not have access to the research facilities may not benefit from this research.
What this research studies
This research investigates the largely unexplored noncoding regions of the human genome, which make up about 98% of our DNA. Using advanced CRISPR-Cas9 technology, the study aims to conduct functional screens in live animal models to uncover the roles these noncoding elements play in various biological processes. By observing how these genetic elements affect behaviors and physiological responses in whole organisms, the research seeks to provide insights that are not possible through traditional cell culture methods. This approach could lead to a better understanding of complex conditions such as cancer and neurodevelopmental disorders.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic contributions to diseases, potentially informing new treatment strategies.
How similar studies have gone: Previous research using CRISPR technology in animal models has shown promise in elucidating genetic functions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Parvez, Saba — Northwestern University at Chicago
- Study coordinator: Parvez, Saba
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.