Understanding the effects of biological and social factors on the mental health of advanced head and neck cancer survivors receiving immunotherapy
Official title: Biological and social determinants of psychosocial sequelae in advanced head and neck cancer survivors receiving immunotherapy
Funded at Emory University · NIH-10938261 · Data updated 2026-11-12
This study is looking at how both biological and social factors affect the mental health and quality of life of people with advanced head and neck cancer who are receiving immunotherapy, so we can better understand the challenges they face and improve support for their well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 27, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $664,304 |
| NIH project number | 1R01CA281873-01A1 |
| Project ID | NIH-10938261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with advanced head and neck cancer who are receiving immunotherapy.
✕Less likely to help
Patients with early-stage head and neck cancer or those not receiving immunotherapy may not benefit from this research.
What this research studies
This research investigates how biological and social factors influence the mental health and quality of life of patients with advanced head and neck cancer who are undergoing immunotherapy. It aims to identify the psychosocial challenges these patients face, such as fatigue and depression, which can worsen their overall health outcomes. By examining the unique side effects of treatment and the uncertainties surrounding their prognosis, the study seeks to provide insights that could lead to better support and care strategies for these patients. The findings may help healthcare providers tailor interventions to improve the well-being of cancer survivors.
Why it matters
Potential benefit: If successful, this research could lead to improved mental health support and care strategies for advanced head and neck cancer survivors, enhancing their quality of life and survival rates.
How similar studies have gone: While there is limited evidence specifically on psychosocial burdens related to immunotherapy in head and neck cancer, similar research in other cancer types has shown promising results in understanding and addressing these challenges.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Xiao, Canhua — Emory University
- Study coordinator: Xiao, Canhua
Related research
Other NIH-funded projects on the same topics.
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Biological and social factors shaping psychosocial outcomes in advanced head and neck cancer patients on immunotherapy
This grant studies how biology and social factors influence mental and emotional well-being in people with advanced head and neck cancer who are receiving immunotherapy.
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Understanding emotional and social challenges for people with advanced head and neck cancer on immunotherapy
This project aims to understand the emotional and social challenges faced by patients with advanced head and neck cancer who are receiving immunotherapy.
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Senescent T cells and immunotherapy resistance in head and neck cancer
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Autologous organoids and humanized mice to test head and neck cancer immunotherapy
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Radiation-related scarring and related effects in head and neck cancer survivors
A study looking at how fibrosis from radiation affects neck movement, swallowing, and daily life in people who have survived head and neck cancer.
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Microbubble-boosted immunotherapy for head and neck cancer
A small NIH-funded project will test whether injecting tiny bubbles into the bloodstream and using ultrasound can boost immunotherapy in people with head and neck cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.