Understanding the complexity of glioblastoma tumors
Systems biology of intratumoral heterogeneity in glioblastoma
This study is looking at how different types of glioblastoma tumors behave and change when treated, with the goal of finding better ways to help patients live longer and improve their chances of recovery by testing existing medications that might work against stubborn tumor cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11009932 on NIH RePORTER |
What this research studies
This research investigates the diverse characteristics of glioblastoma (GBM) tumors, focusing on how different tumor cell types interact and change in response to treatment. It aims to uncover the reasons behind the poor survival rates and high recurrence of GBM by studying the shifts in tumor cell types caused by standard therapies. The approach includes analyzing patient-derived glioma stem-like cells to identify new treatment options that could improve patient outcomes. By repurposing existing FDA-approved drugs, the research seeks to find effective therapies that can target resistant tumor cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing or have undergone standard treatment.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, significantly improving survival rates for patients.
How similar studies have performed: Previous research has shown promise in using repurposed drugs to target glioma stem-like cells, indicating a potential for success in this approach.
Where this research is happening
Seattle, United States
- Institute for Systems Biology — Seattle, United States (Active)
Researchers
- Principal investigator: Baliga, Nitin S — Institute for Systems Biology
- Study coordinator: Baliga, Nitin S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.