Understanding the causes of thrombotic microangiopathy in children after stem cell transplants
Official title: Initiators of thrombotic microangiopathy
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10992178 · Data updated 2026-11-12
This study is looking at a serious condition called thrombotic microangiopathy (TMA) that can affect kids after they have a stem cell transplant, and the researchers want to find out if viral infections, like BK polyomavirus, are triggers for this condition to help improve how we diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $600,648 |
| NIH project number | 5R01HL171046-02 |
| Project ID | NIH-10992178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have undergone hematopoietic stem cell transplantation.
✕Less likely to help
Patients who have not undergone hematopoietic stem cell transplantation or are older than 11 years may not benefit from this research.
What this research studies
This research investigates thrombotic microangiopathy (TMA), a serious condition affecting children who have undergone hematopoietic stem cell transplants. The team aims to identify specific triggers for TMA, particularly focusing on the role of viral infections like BK polyomavirus. By analyzing blood samples and using advanced proteomic techniques, the researchers hope to uncover the mechanisms behind TMA and improve diagnostic criteria and treatment options. This work builds on previous findings that link complement dysregulation to TMA outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for TMA, significantly improving survival rates for affected children.
How similar studies have gone: Previous research has shown promising results in understanding and managing TMA, particularly with the use of complement blockade, indicating that this area of study has potential for significant advancements.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Jodele, Sonata — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Jodele, Sonata
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.