Understanding the causes of Huntington's disease
Molecular Mechanisms of Pathogenesis in Huntington’s disease
This study is looking into how Huntington's disease affects the brain at a cellular level, aiming to find out what goes wrong because of a gene mutation, with the hope of discovering new treatments to help those living with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11086644 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind Huntington's disease, a genetic neurodegenerative disorder. It aims to explore how specific cellular processes are disrupted due to a mutation in the HTT gene, which leads to the accumulation of harmful proteins in the brain. By utilizing advanced technologies like single-cell RNA sequencing and mass spectrometry, the research seeks to identify critical interactions that influence the onset and progression of the disease. The ultimate goal is to uncover potential therapeutic targets that could lead to new treatments for patients suffering from Huntington's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease or those at risk due to family history.
Not a fit: Patients with other neurodegenerative disorders unrelated to Huntington's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that modify the course of Huntington's disease.
How similar studies have performed: Previous research has shown promise in understanding the molecular basis of neurodegenerative diseases, but this specific approach to Huntington's disease is relatively novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Thompson, Leslie Michels — University of California-Irvine
- Study coordinator: Thompson, Leslie Michels
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.