Understanding the causes of chronic autoimmune endocrine diseases.
Official title: Mediators of chronicity in autoimmune endocrinopathies.
Funded at University of California Los Angeles · NIH-10845210 · Data updated 2026-11-12
This study is looking into how certain factors in the body keep autoimmune diseases like Type 1 Diabetes going, with the hope of finding new ways to help people manage their condition better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 10, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $315,515 |
| NIH project number | 1U19AI181729-01 |
| Project ID | NIH-10845210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autoimmune endocrinopathies, such as Type 1 Diabetes or autoimmune thyroiditis.
✕Less likely to help
Patients with non-autoimmune endocrine disorders or those who do not have chronic autoimmune conditions may not benefit from this research.
What this research studies
This research investigates the underlying mechanisms that lead to chronic autoimmune endocrine diseases, such as Type 1 Diabetes. It focuses on how certain molecular and epigenetic factors contribute to the persistence of these conditions, which often require lifelong hormone replacement therapy. By studying the conversion of immune cell progenitors into pathogenic cells, the research aims to uncover potential new treatment strategies that could improve patient outcomes. The approach includes both laboratory experiments and analysis of human immune cells to validate findings.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage or even reverse chronic autoimmune endocrine diseases.
How similar studies have gone: Previous research has shown promise in understanding autoimmune mechanisms, but this specific approach focusing on epigenetic factors in chronicity is relatively novel.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Butte, Manish J — University of California Los Angeles
- Study coordinator: Butte, Manish J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.