Understanding the causes of benign prostatic hyperplasia using mouse models
Official title: Validating Mouse Models of Prostatic Hyperplasia
Funded at Endeavor Health Clinical Operations · NIH-11145150 · Data updated 2026-11-12
This study is looking at benign prostatic hyperplasia (BPH), a condition that makes it hard for men to urinate, by comparing mice with BPH to human tissue to find better ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endeavor Health Clinical Operations NIH-funded |
| Lab location | 1 site (Evanston, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $347,010 |
| NIH project number | 5P20DK140417-02 |
| Project ID | NIH-11145150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men experiencing symptoms of benign prostatic hyperplasia.
✕Less likely to help
Patients with prostate conditions unrelated to benign prostatic hyperplasia may not benefit from this research.
What this research studies
This research investigates benign prostatic hyperplasia (BPH), a common condition that causes urinary flow issues in men. By using advanced techniques like single-cell RNA sequencing, the study aims to compare mouse models of BPH with human tissue to better understand the immune environment and inflammation associated with the condition. The goal is to identify which mouse models accurately reflect human BPH, thereby improving future research and treatment strategies. This could lead to more effective therapies for patients suffering from BPH.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with benign prostatic hyperplasia.
How similar studies have gone: Previous research has shown promise in using mouse models to study human diseases, indicating potential success for this approach.
Where this research is happening
-
Endeavor Health Clinical Operations
Evanston, United States Active
Researchers
- Principal investigator: Vickman, Renee E. — Endeavor Health Clinical Operations
- Study coordinator: Vickman, Renee E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.