TNF blockers and enlarged prostate in aging men
Official title: Effects of TNF Blockade on Human BPH/LUTS
Funded at Endeavor Health Clinical Operations · NIH-11354004 · Data updated 2026-11-12
A study explores whether blocking TNF can help reduce symptoms and enlargement of the prostate in men with BPH/LUTS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endeavor Health Clinical Operations NIH-funded |
| Lab location | 1 site (Evanston, United States) |
| Project start | August 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $686,645 |
| NIH project number | 5R01DK135516-04 |
| Project ID | NIH-11354004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Men with benign prostatic hyperplasia and lower urinary tract symptoms who have not achieved adequate relief with standard medications.
✕Less likely to help
Men without BPH/LUTS or those who do not have inflammatory components related to TNF signaling may not benefit.
What this research studies
This project looks at how inflammation linked to autoimmune conditions might influence benign prostatic hyperplasia and its symptoms. It builds on prior findings that TNF-inhibitors may reduce BPH diagnoses and prostate size in models, and it will test this approach in a human context. Researchers will integrate clinical data and biological insights to understand whether targeting TNF can improve urinary symptoms and potentially reduce the need for surgery. The overall goal is to find safer, more effective options for men whose BPH/LUTS do not respond well to standard medications.
Why it matters
Potential benefit: If successful, the study could lead to new treatments that lessen urinary symptoms and shrink the prostate, improving daily life for men with BPH/LUTS.
How similar studies have gone: Previous work suggests TNF-related therapies can influence prostate inflammation and growth in models and observational data, but human trials are still needed.
Where this research is happening
-
Endeavor Health Clinical Operations
Evanston, United States Active
Researchers
- Principal investigator: Hayward, Simon W — Endeavor Health Clinical Operations
- Study coordinator: Hayward, Simon W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.