Understanding the causes of autoimmune diseases and their early development
Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis
This study is looking at how certain changes in the body, like imbalances in gut bacteria and ongoing inflammation, might lead to autoimmune diseases such as rheumatoid arthritis, especially in people who are at risk, so we can better understand what triggers these conditions.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10908343 on NIH RePORTER |
What this research studies
This research focuses on identifying the molecular origins and mechanisms that lead to autoimmune diseases, particularly in individuals at risk. By studying the role of dysbiosis and chronic inflammation at mucosal sites, the researchers aim to understand how these factors contribute to the loss of tolerance to autoantigens, which can trigger conditions like rheumatoid arthritis. The project involves a collaborative effort with various cores dedicated to administrative support, data sciences, and mucosal immunobiology, utilizing advanced immunologic techniques to study both preclinical and active disease phases in recruited cohorts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for developing autoimmune diseases, particularly those with early signs of dysbiosis or chronic inflammation.
Not a fit: Patients who are not at risk for autoimmune diseases or who have already been diagnosed with advanced stages of these conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of mucosal immunobiology in autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Holers, Vernon Michael — University of Colorado Denver
- Study coordinator: Holers, Vernon Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.