Understanding the causes of a specific type of childhood brain cancer.
Oncogenic mechanisms underlying GLI2-amplified medulloblastoma
This study is looking at a type of brain tumor called medulloblastoma, which is common in kids and can be really tough to treat, especially the GLI2-amplified kind; researchers want to understand how this tumor grows so they can find better ways to help children who have it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11042848 on NIH RePORTER |
What this research studies
This research focuses on medulloblastoma, the most common malignant brain tumor in children, particularly the GLI2-amplified subtype which has a very poor prognosis. The study aims to uncover the cellular and molecular mechanisms that drive this type of tumor, using an engineered mouse model to explore how GLI2 influences tumor development. By identifying the specific cells involved and the pathways activated in these tumors, the research seeks to find new therapeutic targets that could lead to more effective treatments for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with GLI2-amplified medulloblastoma, particularly those under 11 years old.
Not a fit: Patients with other subtypes of medulloblastoma or those who are older than 11 years may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for children with GLI2-amplified medulloblastoma, significantly improving survival rates.
How similar studies have performed: Other research has shown promise in targeting specific pathways in similar types of tumors, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Washington, United States
- Children's Research Institute — Washington, United States (Active)
Researchers
- Principal investigator: Pei, Yanxin — Children's Research Institute
- Study coordinator: Pei, Yanxin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.