Understanding the 3D structures of proteins related to antibiotic resistance
Official title: Centers for Research on Structural Biology of Infectious Diseases: Antibacterial Resistance Research Activities
Funded at Northwestern University at Chicago · NIH-11160415 · Data updated 2026-11-12
This study is looking at the shapes of proteins from germs that cause infections to help find better ways to treat illnesses, especially those caused by bacteria that don't respond to regular antibiotics, so patients can have more effective options for getting better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,526,050 |
| NIH project number | 75N93022C00035-P00010-9999-3 |
| Project ID | NIH-11160415 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant pathogens.
✕Less likely to help
Patients with infections that are not caused by the targeted antibiotic-resistant pathogens may not benefit from this research.
What this research studies
This research focuses on using advanced structural biology techniques to determine the three-dimensional atomic structures of proteins from various infectious disease-causing organisms. By characterizing these structures, researchers aim to understand how these proteins function at a molecular level, which could lead to new strategies for combating antibiotic resistance. Patients may benefit from this research as it could inform the development of more effective treatments for infections caused by resistant bacteria.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies to treat infections caused by antibiotic-resistant bacteria.
How similar studies have gone: Other research has shown success in using structural biology to inform drug development against antibiotic-resistant bacteria, indicating a promising approach.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Satchell, Karla — Northwestern University at Chicago
- Study coordinator: Satchell, Karla
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.